Through the judicious combination of expert insight and the investigation of multiple conditions in parallel we can move very fast to get the best performance out of any process.
Optimizing a step employs 1-2 synthetic chemists plus analytical support. All studies are conducted within a smooth and well-coordinated workflow:
Overall step efficiency (yield, selectivity, volume-time productivity, cost of raw materials).
Identification of critical parameters & optimization (broad screening followed by fine-tuning of reaction parameters).
Optimization or work-up; isolation & purification (elimination of chromatography).
Robustness assessment, in process configured reactors.
Preliminary safety studies (thermal hazard evaluation of product intermediates/reaction mixtures & prediction of large-scale effects).
Synthesis of representative batches.